Kyasanur Forest Disease


Species Incubation period Clinical signs
Humans 3-8 days Biphasic course of illness and fever. Sudden onset of fever and headache, back pain, prostration. After a febrile period of 1-2 weeks, CNS symptoms begin to develop; a mild meningoencephalitis frequently occurs. A small proportion of patients develop coma or bronchopneumonia prior to death. 2-10% fatality.
Cattle, sheep, goats -- KFD-specific antibody titers can be present but not considered a reservoir
Grey langur (Presbytis entellus) -- --
Bonnet macaque (Macaca radiata) After experimental infection, diarrhea at 4dpi; death by 7dpi Diarrhea, dehydration, lymphopenia, death.
Rats: Ratus rattus wroughtoni R. blandfordi No disease After experimental infection, R. r. wroughtoni, R. blandfordi exhibited low viral titers, no morbidity or mortality
Mice: Mus booduga Vandeleuria oleracea -- --
Palm Squirrel Funambulus tristriatus numarius 2-4 days after experimental infection Disseminated nonsuppurative encephalitis, death.
Shrew: Suncus murinus -- --

The main tick vector is Haemaphysalis spinigera.

References:

Gritsun TS et al. Tick-borne encephalitis. Antiviral Research, 57:129-146, 2003


Kenyon RH et al. Infection of Macaca radiata with viruses of the tick-borne encephalitis group. Microbial Pathogenesis, 13:399-409, 1992.


Kyasanur Forest Disease, CDC Factsheet:
http://www.cdc.gov/ncidod/dvrd/spb/mnpages/dispages/kyasanur.htm


Material Data Safety Sheet: Kyasanur Forest Disease Virus. Public Health Agency of Canada, 2001 - http://www.phac-aspc.gc.ca/msds-ftss/msds91e.html


Webb HE. Kyasanur forest disease virus in three species of rodents. Transactions of the Royal Society of Tropical Medicine and Hygiene, 59(2):205-211, 1965


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[ This page was last updated on Thursday, May 17, 2007. ]